Table 2.
Numbers of up- and down-regulated genes associated with viral infection-related groups.
| Sample group | Abbreviation | Samples | Controls | Up- regulated1 |
Down-regulated1 | Interferon-stimulated genes 2 |
|---|---|---|---|---|---|---|
| Cytomegalovirus primary infection | CMV_pr | 11 | 12 | 833 (792) | 943 (888) | 10 (p <10-4) |
| Cytomegalovirus seropositive healthy donors | CMV_pos | 25 | 12 | 8 (0) | 8 (0) | 0 |
| Ebstein-Barr acute infection | EBV_a | 3 | 9 | 2343 (436) | 2373 (291) | 20 (p <10-4) |
| Ebstein-Barr latent infection | EBV_l | 12 | 9 | 3255 (3166) | 3315 (3201) | 11 (p = 0.4) |
| Hepatitis B chronic infection | HBV | 12 | 5 | 936 (666) | 1097 (894) | 12 (p <10-4) |
| Hepatitis C chronic infection | HCV | 10 | 6 | 136 (89) | 308 (216) | 7 (p <10-4) |
| Human T-cell leukemia virus type 1 infection | HTLV_1 | 6 | 3 | 430 (0) | 495 (0) | 2 (p = 0.12) |
| Human immunodeficiency virus infection | HIV | 5 | 4 | 192 (0) | 108 (0) | 18 (p <10-4) |
| Dengue hemorrhagic fever | DHF | 10 | 8 | 878 (7) | 608 (5) | 14 (p <10-4) |
| Dengue fever | DF | 8 | 8 | 384 (0) | 368 (0) | 24 (p <10-4) |
| Severe acute respiratory syndrome | SARS | 10 | 4 | 720 (79) | 836 (95) | 3 (p = 0.88) |
| Coronovirus Disease 2019 (COVID-19) - patients with evident clinical symptoms | COVID19 | 13 | 22 | 1605 (1554) | 2004 (1925) | 29 (p <10-4) |
| Coronovirus Disease 2019 (COVID-19) - patients in Intensive Care Unit (ICU) | COVID19_ICU | 4 | 17 | 2925 (2751) | 2640 (2204) | 7 (p = 0.76) |
| Coronovirus Disease 2019 (COVID-19) - patients with severe disease, but not in Intensive Care Unit (ICU) | COVID19_Sev | 8 | 17 | 2104 (1899) | 1698 (1331) | 18 (p <10-4) |
| Coronovirus Disease 2019 (COVID-19) - patients with moderate disease | COVID19_Mod | 4 | 17 | 1699 (1438) | 1562 (1108) | 31 (p <10-4) |
1Numbers of up- and down-regulated genes with |logFC| > 0.5 and unadjusted p-value < 0.05. The corresponding numbers of genes with adjusted p value < 0.05 are shown in brackets.
2Numbers of up-regulated genes intersected with the list of 50 interferon-stimulated genes along with statistical significance of intersections (p values).