Table 1.
Patient characteristics
| dMMR (n = 44) | pMMR (n = 57) | p-value | |
|---|---|---|---|
| Age at diagnosis, years | |||
| Median | 75 | 73 | 0.65 |
| Range | 23–89 | 45–90 | |
| Sex, n (%) | 0.18 | ||
| Male | 15 (34) | 27 (47) | |
| Female | 29 (66) | 30 (53) | |
| BMI, kg/m2 | |||
| Mean | 26.2 | 27.7 | 0.21 |
| Range | 15.6–50.3 | 13.1–43.8 | |
| Primary tumour location, n (%) | 0.0095 | ||
| Appendix | 1 (2) | 0 (0) | |
| Caecum | 12 (27) | 14 (25) | |
| Ascending colon | 15 (34) | 13 (23) | |
| Hepatic flexure | 3 (7) | 0 (0) | |
| Transverse colon | 9 (20) | 5 (9) | |
| Splenic flexure | 2 (5) | 5 (9) | |
| Descending colon | 0 (0) | 2 (4) | |
| Sigmoid colon | 2 (5) | 17 (30) | |
| Rectosigmoid junction | 0 (0) | 1 (2) | |
| Side of colon affected, n (%) | <0.001 | ||
| Right | 40 (91) | 32 (56) | |
| Left | 4 (9) | 25 (44) | |
| Presentation, n (%) | 0.86 | ||
| Incidental | 1 (2) | 3 (5) | |
| Screening | 10 (23) | 13 (23) | |
| Symptoms | 27 (61) | 35 (61) | |
| Emergency | 6 (14) | 6 (11) | |
| Chemotherapy treatment, n (%) | 0.029 | ||
| None | 41 (93) | 44 (77) | |
| Adjuvant | 3 (7) | 13 (23) | |
| Neutrophils, ×109/L | |||
| Mean (SD) | 6.54 (3.32) | 5.15 (2.04) | 0.012 |
| Range | 1.55–17.87 | 1.19–11.16 | |
| Lymphocytes, ×109/L | |||
| Mean (SD) | 1.62 (0.73) | 1.53 (0.52) | 0.50 |
| Range | 0.19–4.00 | 0.71–3.08 | |
| Neutrophil:lymphocyte ratio | 0.13 | ||
| Mean (SD) | 5.63 (8.62) | 3.77 (2.14) | |
| Range | 1.19–59.05 | 0.70–11.52 | |
| Histology, n (%) | 0.0045 | ||
| Adenocarcinoma | 27 (61) | 49 (86) | |
| Mucinous adenocarcinoma | 17 (39) | 8 (14) | |
| Differentiation, n (%) | 0.0063 | ||
| Well/moderate | 29 (66) | 52 (91) | |
| Poor | 13 (30) | 4 (7) | |
| Unknown/not applicable a | 2 (5) | 1 (2) | |
| Stage b , n (%) | 0.27 | ||
| I | 11 (25) | 12 (21) | |
| II | 21 (48) | 21 (37) | |
| III | 12 (27) | 21 (37) | |
| IV | 0 (0) | 3 (5) |