TABLE 3.

NIH Toolbox cognition battery age-adjusted standard scores compared with normative data.

	Entire sample			ALL			CNS tumor			SCD
	M	SD	p-value*	M	SD	p-value*	M	SD	p-value*	M	SD	p-value*
Working memory	95.5 N = 52	(13.3)	.033	93.4 N = 26	(14.5)	.026	98.5 N = 11	(13.2)	.741	97.1 N = 15	(11.1)	.440
Processing speed	88.0 N = 51	(20.8)	<.001	85.6 N = 25	(19.0)	<.001	82 N = 11	(21.7)	<.001	96.3 N = 15	(22.0)	.759
Episodic memory	97.4 N = 51	(14.2)	.327	99.5 N = 26	(15.3)	.866	95.2 N = 11	(12.6)	.290	95.1 N = 14	(13.3)	.488
Inhibitory control and attention	91.8 N = 52	(13.9)	<.001	92.1 N = 26	(14.4)	.008	85.4 N = 11	(10.3)	.001	96.0 N = 15	(14.5)	.342
Cognitive flexibility	92.7 N = 52	(14.0)	<.001	93.4 N = 26	(11.7)	.026	91.7 N = 11	(15.9)	.068	92.3 N = 15	(17.1)	.043
Cognition fluid composite	88.7 N = 50	(14.1)	<.001	88.8 N = 25	(12.9)	<.001	84.1 N = 11	(16.3)	<.001	92.1 N = 14	(14.2)	.118

ALL, acute lymphoblastic leukemia; CNS, central nervous system; SCD = sickle cell disease.

^*Significance level after Bonferroni correction for multiple comparisons p ≤ .0016.