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. Author manuscript; available in PMC: 2023 Oct 3.
Published in final edited form as: J Med Chem. 2022 Dec 20;66(1):577–595. doi: 10.1021/acs.jmedchem.2c01499

Figure 3.

Figure 3.

Warm-water tail immersion assays results of target compounds in mice (n = 5) at 56 ± 0.1 °C. (A) Antinociception effects of compounds 1–17 (10 mg/kg). (B) Antinociception effects of compounds 18–34 (10 mg/kg). (C) Blockage of the morphine-mediated antinociception of selected compounds (10 mg/kg) in the presence of morphine (10 mg/kg). The tested compound was injected subcutaneously at time 0. Morphine was administered after 5 min, and 20 min after the morphine injection, tail flick was conducted using warm water. Saline and morphine were the negative and positive controls. Data are presented as mean values ± SD. *P < 0.05 compared to vehicle; **P < 0.01 compared to vehicle.