Table 2.
Associations Between Total PA, Moderate-to-Vigorous PA, Light-Intensity PA, SB, and Step Count and CVD Mortality or CVD Event
| First author year | CVD outcome | Total PA |
MVPA | Light-intensity PA |
SB | Step count |
|---|---|---|---|---|---|---|
| Dohrn 201838 |
CVD mortality | AC/day (multiply by 1,000): T1: HR=1.0 (ref) T2: HR=0.27 (0.06, 1.16) T3: HR=0.09 (0.01, 0.93) |
Minute/day T1: HR=1.0 (ref) T2: HR=0.22 (0.06–0.74) T3: HR=0.11 (0.03–0.56) |
Minute/day T1: HR=1.0 (ref) T2: HR=0.48 (0.19, 1.19) T3: no event |
Minute/day T1: HR=1.0 (ref) T2: HR=1.63 (0.36, 7.28) T3: HR=5.51 (1.43, 21.23) |
NA |
| Evenson 201639 |
CVD mortality | AC/minute Q1: HR=1.0 (ref) Q2: HR=0.49 (0.29, 0.83) Q3: HR=0.42 (0.22, 0.81) Q4: HR=0.35 (0.15, 0.84) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=0.49 (0.28, 0.84) Q3: HR=0.18 (0.07, 0.46) Q4: HR=0.48 (0.23, 1.03) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=1.06 (0.65, 1.72) Q3: HR=0.68 (0.36, 1.26) Q4: HR=0.90 (0.44, 1.84) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=1.12 (0.54, 2.31) Q3: HR=1.03 (0.50, 2.12) Q4: HR=1.44 (0.71, 2.90) |
NA |
| MJ LaMonte 201843 |
CVD mortality | VMC minute/day T1: risk ratio=1.0 (ref) T2: risk ratio=0.64 (0.44, 0.94) T3: risk ratio=0.29 (0.16, 0.53) |
Minute/day T1: risk ratio=1.0 (ref) T2: risk ratio=0.68 (0.45, 0.99) T3: risk ratio=0.42 (0.24, 0.75) |
Minute/day low-intensity: T1: risk ratio=1.0 (ref) T2: risk ratio=0.69 (0.47, 1.02) T3: risk ratio=0.64 (0.41, 0.99) high-intensity: T1: risk ratio=1.0 (ref) T2: risk ratio=0.50 (0.34, 0.74) T3: risk ratio=0.30 (0.17, 0.51) |
NA | NA |
| Dempsey 202022 |
CVD eventa | Higher levels of TPA were associated with lower incident CVD risk in a nonlinear manner. (Ref: 120 cpm/day) |
Higher levels of MVPA were associated with lower incident CVD risk in a nonlinear manner. (Ref: no MVPA) |
Association was attenuated after covariate and MVPA adjustment (Ref: 3 hours/day) |
Positive associations with a steeper relationship beyond 11 hours/day, attenuated after adjusted for covariates and MVPA (ref: 8 hours/day) | NA |
| KE Ensrud 201444 |
CVD mortality | NA | Minute/day Q1 (most active): HR=1.0 (ref) Q2: HR=1.60 (0.82, 3.11) Q3: HR=1.79 (0.94, 3.42) Q4: HR=2.86 (1.50, 5.45) |
Minute/day Q1 (most active): HR=1.0 (ref) Q2: HR=1.29 (0.67, 2.49) Q3: HR=1.92 (1.04, 3.55) Q4: HR=1.73 (0.90, 3.34) |
Minute/day Q1 (least sedentary): HR=1.0 (ref) Q2: HR=1.59 (0.91, 2.75) Q3: HR=1.12 (0.63, 2.00) Q4: HR=1.71 (0.99, 2.97) |
NA |
| Bellettiere 201924 |
CVD eventb | NA | NA | NA | Minute/day Q1: HR=1.0 (ref) Q2: HR=1.40 (1.03, 1.89) Q3: HR=1.40 (1.03, 1.89) Q4: HR=1.53 (1.09, 2.14) |
NA |
| Dohrn 201948 |
CVD eventc (c) | AC/day (multiply by 1000): 1,000): T1: HR=1.0 (ref) T2: HR=0.70 (0.46, 1.05) T3: HR= 0.67 (0.44, 1.04) |
Minute/day T1: HR=1.0 (ref) T2: HR=0.77 (0.52, 1.19) T3: HR=0.52 (0.33, 0.82) |
Minute/day T1: HR=1.0 (ref) T2: HR=1.03 (0.70, 1.53) T3: HR=0.92 (0.60, 1.42) |
Minute/day T1: HR=1.0 (ref) T2: HR=1.05 (0.68, 1.64) T3: HR=1.41 (0.91, 2.20) |
NA |
| Jefferis 201946 |
CVD eventd | NA | Minute/day Q1: HR=1.0 (ref) Q2: HR=0.62 (0.38, 1.00) Q3: HR=0.28 (0.14, 0.55) Q4: HR=0.34 (0.16, 0.74) every 10-minute/day increase: HR=0.89 (0.80, 0.99) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=0.93 (0.57, 1.50) Q3: HR=0.59 (0.33, 1.06) Q4: HR=0.97 (0.53, 1.80) every 30-minute/day increase: HR=0.99 (0.89, 1.11) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=0.70 (0.38, 1.28) Q3: HR=0.81 (0.43, 1.52) Q4: HR=0.94 (0.45, 1.94) every 30-minute/day increase: HR=1.01 (0.90, 1.13) |
Steps/day: Q1: HR=1.0 (ref) Q2: HR=0.75 (0.47, 1.20) Q3: HR=0.44 (0.25, 0.77) Q4: HR=0.34 (0.17, 0.67) Every 1,000 step/day increase: HR=0.86 (0.78, 0.95) |
| LaCroix 201950 |
CVD evente | NA | Minute/day Q1: HR=1.0 (ref) Q2: HR=0.75 (0.61, 0.93) Q3: HR=0.66 (0.52, 0.84) Q4: HR=0.71 (0.54, 0.93) |
Minute/day Q1: HR=1.0 (ref) Q2: HR=1.05 (0.84, 1.30) Q3: HR=0.90 (0.71, 1.14) Q4: HR=0.82 (0.63, 1.07) every 1-hour/day increase: HR=0.92 (0.85, 0.99) |
NA | NA |
| Saint-Maurice 202021 |
CVD mortality | NA | NA | NA | NA | Step/day Qn1: HR=1.0 (ref) Qn2: HR=0.68 (0.60, 0.76) Qn3: HR=0.49 (0.40, 0.60) Qn4: HR=0.40 (0.30, 0.52) Qn5: HR=0.35 (0.24, 0.52) |
Note: For mg, 1 mg = 0.00981 ms–2. Associations were presented by exposure category (e.g., T, Q).
Total fatal and nonfatal incidents of CVD.
CVD events (include the first occurrence of an MI, revascularization, hospitalized angina, heart failure, stroke, or death attributable to any CVD among women without that event) and CHD events (nonfatal MI or coronary death) as a separate endpoint.
CVD events and mortality.
Fatal and nonfatal CHD, stroke, heart failure.
CVD events (include CHD, revascularization, carotid artery disease, hospitalized angina, congestive heart failure, stroke, and other CVD deaths).
AC, accelerometer count derived from Actigraph accelerometer; CHD, coronary heart disease; CVD, cardiovascular disease; HR, hazard ratio; mg, milligravity; MI, myocardial infarction; MVPA, moderate-to-vigorous intensity physical activity; NA, not applicable; PA, physical activity; Q, quartile; Qn, quintile; T, tertile; VMC, vector magnitude counts derived from accelerometer.