Table 1.
Patient demographics
| Patient | Diagnosis | Age | Prior Chemotherapy Regimens (#) | Previous Radiation Tx | Time from Dx to Tx (months) | Disease at Trial Entry | HSV1716 Dose (iu) | Location of Injected Tumor |
|---|---|---|---|---|---|---|---|---|
| HSV01 | Parameningeal Rhabdomyosarcoma | 13 | VCR, Irino, Doxo, CTX, Etop; Navelbine/CTX; Vorinostat/Bortezomib (3) | IMRT 50.4 Gy | 23 | Large local recurrence; lung metastases | 1 × 105 | Skull base |
| HSV02 | Extremity Ewing Sarcoma | 21 | CTX/Topo/VCR/Ifos/Carbo/Etop; CTX/Topo; Irino; Gem/Tox (4) | Yes | 75 | Multiple lung metastases | 1 × 105 | Left Lung Metastasis |
| HSV03 | Spinal/paraspinal MPNST | 19 | Ifos/Doxo; Carbo/Etop x2; Sirolimus; Vorinostat/Bortezomib (4) | IMRT 59.4 Gy to abd; IMRT 45 Gy to pelvis | 43 | L3 Paraspinal mass; spinal canal lesions lower thoracic to sacrum | 1 × 105 | Paraspinal mass (L3) |
| HSV04 | Thoracic osteosarcoma (in context of Li Fraumeni) | 19 | Doxo/Cisplat/MTX; Gem/Dox; IMC-A12/Tem; Etop (4) | None | 27 | 2 paraspinal masses, lung metastases, humeral lesion, L2 vertebral body lesion | 2 × 106 | Paraspinal mass at T8/9 (recurrent primary tumor) |
| HSV05 | Clival chordoma | 10 | VCR/Doxo/CTX/Ifos/Etop; Erlotinib; Sirolimus (3) | 74 Gy | 53 | Clival recurrence, lesions in orbit, posterior to cerebellum and hard palate | 2 × 106 | Left orbital metastasis |
| HSV06 | Retroperitoneal Rhabdomyosarcoma | 8 | VCR/Dactino/CTX; Irino/Doxo; Ifos/Etop; Vinorelbine/Bevaz; Tem; Topo (4) | 41.4 Gy primary; 3 Gy spinal | 50, 51 | Localized large tumor recurrence at primary tumor site; no metastatic disease | 2 × 106 | Recurrent Retroperitoneal mass |
| HSV07 | Renal Cell Carcinoma of the left kidney | 16 | Sunitinib (1) | None | 7 | Localized recurrence retroperitoneum, supraclavicular node metastases; localized node metastases | 1 × 107 | Recurrent retroperitoneal mass |
| HSV08 | Osteosarcoma of the left tibia | 16 | Ifos/Etop; Gem/Dox; Zometa x2; Bev; Oxali/Irino; Doxo/Cisplat; Sorafenib (7) | None | 45 | Lung metastases (multiple) | 1 × 107 | Right pleural metastasis |
| HSV09 | Chondrosarcoma of the left distal femur | 30 | IDH-1 inhibitor (1) | 60 Gy to leg; 54 Gy leg | 48 | Innumerable bilateral pulmonary metastases; possible local recurrence in the distal left femoral prosthesis and left calf regions | 1 × 107 | 2 right and 1 left upper lobe lung metastases |