Table 4.
Comparison of the genotype and allele frequencies of SRD5A2 rs12470143 and rs7594951 between different liver fibrosis stages in patients with chronic HBV infection
| Variant | F0–2, n (%) | F3–4, n (%) | χ2 | P value |
|---|---|---|---|---|
|
SRD5A2 rs12470143 Genotype |
||||
| CC | 560 (75.6%) | 165 (62.0%) | 40.479 | < 0.001 |
| CT | 153 (20.6%) | 62 (23.3%) | ||
| TT | 28 (3.8%) | 39 (14.7%) | ||
| Allele | ||||
| C | 1273 (85.9%) | 392 (73.7%) | 78.601 | < 0.001 |
| T | 179 (14.1%) | 140 (26.3%) | ||
|
SRD5A2 rs7594951 Genotype |
||||
| CC | 648 (87.4%) | 199 (74.8%) | 58.253 | < 0.001 |
| CT | 73 (9.9%) | 25 (9.4%) | ||
| TT | 20 (2.7%) | 42 (15.8%) | ||
| Allele | ||||
| C | 1369 (92.4%) | 423 (79.5%) | 66.050 | < 0.001 |
| T | 113 (7.6%) | 109 (20.5%) | ||