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. 2023 Oct 3;14:68. doi: 10.1186/s13293-023-00553-4

Table 5.

Univariate and multivariate analyses of the risk factors associated with HBV-related liver fibrosis in patients with chronic HBV infection (n = 1007)

Variables Univariate analysis Multivariate analysis
OR (95%CI) P OR (95%CI) P
Male 1.98 (1.50, 2.61)  < 0.001 1.84 (1.34, 2.54)  < 0.001
Age > 50 years old 3.41 (2.62, 4.45)  < 0.001 3.61 (2.69, 4.84)  < 0.001
Drinking 1.40 (1.07, 1.85) 0.016 0.95 (0.68, 1.31) 0.735
HOMA-IR ≥ 2.5 1.34 (1.03, 1.74) 0.027 1.35 (1.00, 1.82) 0.05
HBeAg positive 2.27 (1.58, 3.26)  < 0.001 2.14 (1.43, 3.21)  < 0.001
HBsAg load, log IU/mL 6.20 (3.49, 11.02)  < 0.001 6.32 (3.37, 11.88)  < 0.001
HBV load, log IU/mL 1.35 (1.24, 1.45)  < 0.001 1.34 (1.23, 1.46)  < 0.001
HBV genotype C 1.63 (1.17, 2.25) 0.003 1.63 (1.13, 2.35) 0.008
SRD5A2 rs12470143 C > T 1.88 (1.15, 3.06) 0.011 1.79 (1.05, 3.05) 0.033
SRD5A2 rs7594951 C > T 3.36 (1.73, 6.53)  < 0.001 4.55 (2.17, 9.54)  < 0.001