TABLE 3.

Effect of fluconazole on colony count in kidney tissue

Isolate and MICs	Mean ± SE % of control CFU/g kidney tissue at the following fluconazole dose (mg/kg/day):			Pb
	0	1	5	0 vs 1 mg/kg/day	0 vs 5 mg/kg/day
C. albicans
Low/low	100 ± 28	2 ± 1	1 ± 1	0.002	0.002
Low/high	100 ± 35	5 ± 1	1 ± 1	0.014	0.011
High/high	100 ± 28	530 ± 260	56 ± 29	0.118	0.287
C. tropicalis
Low/low	100 ± 16	14 ± 3	4 ± 1	<0.001	<0.001
Low/high	100 ± 19	14 ± 5	9 ± 3	<0.001	0.001
High/high	100 ± 18	24 ± 5	6 ± 1	<0.001	<0.001

^aAs discussed in the text, the numbers of CFU per gram of kidney tissue from mice treated with 0, 1, or 5 mg of fluconazole per kg/day were expressed as a percentage of numbers of CFU per gram in the group not treated with drug. In an analysis of variance for all three doses, the overall P value for the effect of therapy was 0.069 for C. albicans for which the MICs were high/high and <0.002 for all other isolates. In addition, the post-hoc Student-Newman-Keuls procedure found that the reduction in growth for the 1- and 5-mg/kg/day treatment groups did not differ from each other for any isolate but did differ from the reduction in growth for the group receiving no treatment (P < 0.05) for all isolates except the C. albicans isolate for which the MICs were high/high. 

^bFor reference purpose, a simple t test comparing the no-treatment group with the indicated treatment group was performed, and the resulting P value is presented.