Table 2.

Summary results of genome-wide CpGs associated with albuterol exposure in nasal cells

CpG	Chr	Position*	Gene	Discovery			Validation
				ΔDNAm (%)	logFC	p-value	logFC	p-value	FDR
cg10290200	7	128841241	FLNC	− 3.4	− 0.397	2.76 × 10–18	− 0.131	0.328	0.620
cg00483640	6	2623249	MYLK4-LINC01600	− 4.9	− 0.358	2.06 × 10–17	− 0.321	0.003	0.021
cg15833511	20	36628395	SLA2	− 15.3	− 0.318	2.92 × 10–16	− − 0.169	0.102	0.348
cg24254891	22	39999311	FAM83F	− 15.6	− 0.290	4.16 × 10–13	− 0.015	0.906	0.963
cg12510044	22	21761184	MAPK1	− 9.1	− 0.277	9.56 × 10–13	− 0.151	0.152	0.368
cg02424494	2	238291487	PER2	− 2.3	− 0.219	1.49 × 10–11	− 0.202	0.031	0.133
cg03629778	7	130051485	ZC3HC1	− 10.1	− 0.203	2.43 × 10–11	0.039	0.701	0.851
cg05673431	17	27544478	KSR1	− 2.4	− 0.175	4.46 × 10–11	− 0.240	0.004	0.021
cg11023970	10	6295886	PFKFB3	4.4	0.181	1.55 × 10–10	0.052	0.619	0.809
cg03956296	2	39724059	THUMPD2	− 17.7	− 0.475	1.66 × 10–9	NA	NA	NA
cg23032799	11	46274563	CREB3L1	− 6.5	− 0.177	3.48 × 10–9	− 0.264	1.53 × 10–4	0.003
cg08161666	11	13013350	ARNTL	− 16.8	− 0.361	4.20 × 10–9	− 0.318	0.125	0.353
cg10310427	6	30749208	IER3	− 8.2	− 0.169	7.50 × 10–9	− 0.004	0.964	0.964
cg16769649	6	47358617	TNFRSF21	− 8.4	− 0.267	9.55 × 10–9	NA	NA	NA
cg26162522	1	56571443	PPAP2B	− 3.5	− 0.202	1.52 × 10–8	NA	NA	NA
cg16032470	20	33230393	BPIFA1	− 8.8	− 0.175	1.78 × 10–8	NA	NA	NA
cg03068616	6	6678265	LY86	− 12.6	− 0.271	1.97 × 10–8	− 0.174	0.202	0.429
cg16519100	15	83200514	HDGFRP3	23.5	0.271	2.66 × 10–8	− 0.121	0.478	0.734
cg22208174	9	106880861	ZNF462	− 7.6	− 0.239	2.81 × 10–8	NA	NA	NA
cg12845391	6	137224161	IFNGR1	− 4.4	− 0.129	3.38 × 10–8	− 0.043	0.518	0.734
cg12845808	5	141959039	PCDH12	− 7.3	− 0.109	4.54 × 10–8	− 0.012	0.866	0.963
cg03946667	5	136058672	TGFBI	− 5.2	− 0.147	4.63 × 10–8	− 0.052	0.505	0.734

Chr chromosome; logFC log₂(fold-change); SE standard error; FDR false discovery rate

*Genomic positions are indicated in hg38/GRCh38 Genome Assembly.

Significant CpGs in the validation stage are in boldface