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. 2023 Oct 2;21:205. doi: 10.1186/s12915-023-01699-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Serum cross-reactivity with A35R homologs of OPXV strains. A Amino acid sequence alignment of MPXV A35R protein, its homologs from VACV (red), VACV-like (orange), CPXV (yellow), CPXV-like-1 (green), CPXV-like-2 (purple) and CPXV-like-3 (blue) strains. The different amino acid residues (compared to MPXV A35R) are labeled in yellow. Two recombinant A35R homologous proteins, A35R-h1 and A35R-h2, were expressed for serologic ELISA. The A35R-h1 recombinant protein shared the same amino acid sequence with the A35R homologs of five VACV strains (the red arrow line). The A35R-h2 recombinant protein shared the same amino acid sequence with the A35R homologs of one CPXV, five CPXV-like-1, and eight CPXV-like-2 strains (the blue arrow lines). B-E Serologic ELISA AUC values for two VACV-infected donors (B), eight donors with low reactivity against MPXV proteins (C), and the top 13 antibody responders against MPXV proteins (D and E). Red, individuals born before 1980; blue, individuals born after 1980; orange, individuals recovered from previous VACV infection