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. 2023 Oct 2;21:686. doi: 10.1186/s12967-023-04575-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Therapeutic approaches for targeting CSCs. The figure outlines six distinct strategies to target CSCs, including targeting CSC markers and signaling pathways, targeting CSC-associated tumor angiogenesis and metastasis, disrupting CSC niches, targeting epigenetic modifications, exploring immunotherapies, and reprogramming CSCs. VEGF, vascular endothelial growth factor; SDF-1, stromal cell-derived factor-1; HIF-1α, hypoxia-inducible factor 1-alpha; Ang-1, angiopoietin-1; TGF-β, transforming growth factor-beta; EMT, epithelial-mesenchymal transition; FAP, fibroblast activation protein; mAb, monoclonal antibody; ADC, antibody drug conjugate; TAM, tumor-associated macrophage; MDSC, myeloid-derived suppressor cell