Table 1.
Standard neoadjuvant and adjuvant chemotherapy regimens for breast cancer at Charlotte Maxeke Johannesburg Academic Hospital (Gauteng) and Grey’s Hospital (KwaZulu-Natal).
| Regimen | Drugs | Dose (mg/m2) | Cycle length (days) | Cycle number |
|---|---|---|---|---|
| AC | Doxorubicin/Epirubicin | 60/75 | 21 | 4 |
| Cyclophosphamide | 600 | 21 | 4 | |
| AC-T | Doxorubicin/Epirubicin | 60/75 | 21 | 4 |
| Cyclophosphamide | 600 | 21 | 4 | |
| Paclitaxel/Docetaxel | 175/75 | 21 | 4 | |
| FAC | Fluorouracil | 500 | 21 | 6 |
| Doxorubicin/Epirubicin | 50/75 | 21 | 6 | |
| Cyclophosphamide | 500 | 21 | 6 | |
| FAC-T | Fluorouracil | 500 | 21 | 4 |
| Doxorubicin/Epirubicin | 50/75 | 21 | 4 | |
| Cyclophosphamide | 500 | 21 | 4 | |
| Paclitaxel/Docetaxel | 175/75 or 1001 | 21 | 4 | |
| TC | Cyclophosphamide | 500 | 21 | 4 or 6 |
| Paclitaxel/Docetaxel | 175/75 | 21 | 4 or 6 | |
| TAC | Doxorubicin/Epirubicin | 50/75 | 21 | 6 |
| Cyclophosphamide | 500 | 21 | 6 | |
| Paclitaxel/Docetaxel | 175/75 | 21 | 6 | |
| T | Paclitaxel/Docetaxel | 175/75 | 21 | 6 |
1 Varied by treating hospital.
Abbreviations: A, anthracycline; C, cyclophosphamide; F, fluorouracil; T, Taxane.