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Most common (>5% incidence) treatment-related adverse events.
| TRAE, n (%) | All grade | Grade 1 | Grade 2 | Grade 3 |
|---|---|---|---|---|
| Hypertension | 21 (46) | 10 (22) | 9 (20) | 2 (4) |
| Dysphonia | 7 (15) | 7 (15) | ||
| Asthenia | 6 (13) | 2 (4) | 3 (7) | 1 (2) |
| Diarrhea | 5 (11) | 4 (9) | 1 (2) | |
| Fatigue | 4 (9) | 3 (7) | 1 (2) | |
| Rash | 3 (7) | 1 (2) | 2 (4) |
No grade 5 TRAEs occurred during this study. Two grade 4 TRAEs (duodenal ulcer hemorrhage, hyperbilirubinemia) occurred once in a single patient.
Abbreviation: TRAE, treatment-related adverse event.
