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(A) Natural killer cells did not change significantly at C2D1 and C3D1. (B) Naïve cells were increased and effector memory (EM)1 and EM4 cells were decreased among total peripheral CD4+ T cells (*P < .05; **P < .005). (C) Activated (HLA-DR+ or PD-1+ or ICOS+) and proliferating (Ki67+) cells were decreased among total peripheral CD4+ T cells. (D) CTLA4 expression on peripheral CD4+ T cells was increased.
