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. 2023 Jun 5;28(10):919–e972. doi: 10.1093/oncolo/oyad164
Primary Assessment Method: Endometrial Cancer (Cohort 3)
Number of patients screened 14
Number of patients enrolled 10
Number of patients evaluable for toxicity 10
Number of patients evaluated for efficacy 6
Evaluation method RECIST 1.1
Response assessment, CR 0 (0%)
Response assessment, PR 0 (0%)
Response assessment, SD 2 (33.3%)
Response assessment, PD 4 (66.7%)
Median duration assessments 8.9 weeks
Duration of treatment 8.9 weeks
Outcome notes Two patients did not complete 1 cycle; of these, 1patient did not complete 1 cycle due to clinical progression and 1 patient did not complete a cycle due to intercurrent illness (a cerebrovascular accident) after 2 of 4 weekly doses in cycle 1 thought not to be related to ONC201. Two patients had clinical progression and did not have follow-up imaging.