Table 4.
Adverse-effects of CAPTEM chemotherapy (n = 308).
| Grade 1, 2 n (%) |
Grade 3, n (%) | Grade 4, n (%) | Treatment interruption, n (%) | |
|---|---|---|---|---|
| Decreased platelet count | 34 (11.0) | 8 (2.6) | 3 (1.0) | 3 (1.0) |
| Decreased neutrophil count | 34 (11.0) | 1 (0.3) | 3 (1.0) | 4 (1.3) |
| Decreased lymphocyte count | 40 (12.9) | 3 (1.0) | — | |
| Anemia | 85 (27.6) | 10 (3.2) | — | |
| Fatigue | 127 (41.3) | 10 (3.2) | 1 (1.2) | 3 (1.0) |
| Nausea/vomiting | 116 (37.7) | 14 (4.5) | — | 5 (1.6) |
| Constipation | 11 (3.5) | 1 (0.3) | — | |
| Gastrointestinal hemorrhage | 4 (1.3) | 2 (0.6) | — | 2 (0.6) |
| Diarrhea | 34 (11.0) | 3 (1.0) | 2 (0.6) | 2 (0.6) |
| Anorexia | 91 (29.6) | 4 (1.3) | 1 (0.3) | 1 (1.2) |
| Abdominal pain | 27 (8.8) | 2 (0.6) | 1 (0.3) | 2 (0.6) |
| Fever | 4 (6.8) | — | — | |
| Oral mucositis | 42 (13.6) | 4 (1.3) | — | 2 (0.6) |
| Pruritis | 4 (6.8) | — | — | |
| Skin rash | 2 (3.4) | — | — | |
| Palmar-plantar erythrodysesthesia | 58 (18.8) | 4 (1.3) | — | 1 (1.2) |
| Increased blood bilirubin | 15 (4.8) | 5 (1.6) | 1 (0.3) | 1 (1.2) |
| Increased alkaline phosphatase | 22 (7.1) | 4 (1.3) | — | |
| Increased AST | 41 (13.3) | 2 (0.6) | — | 1 (1.2) |
| Increased ALT | 32 (10.4) | 1 (0.3) | — | 1 (1.2) |
| Dehydration | 2 (2.4) | 2 (2.4) | — |