Table 1.

Clinical features and select pathogenic genomic alteration frequencies in 8728 UCB specimens.

	EAS	Non-EAS	P value†	SAS	Non-SAS	P value†	EAS	EUR	P value†	SAS	EUR	P value†
n	205	8523	—	74	8654	—	205	7447	—	74	7447	—
Sex (% male)	0.7122	0.7490	NS	0.7568	0.7481	NS	0.7122	0.7602	NS	0.7568	0.7602	NS
Median age (range)	72 (29-89+)	70 (16-89+)	—	72 (19-89+)	70 16-89+)	—	72 (29-89+)	70 (16-89+)	—	72 (19-89+)	70 (16-89+)	—
Mean age	70.4657	69.3063	NS	69.4054	69.3328	NS	70.4657	69.6562	NS	69.4054	69.6562	NS
GA/tumor	8.0293	8.1165	NS	8.6622	8.1098	NS	8.0293	8.1151	NS	8.6622	8.1151	NS
Genomic ancestry
n	205	8523	—	74	8654	—	205	7447	—	74	7447	—
AFR	0	0.0635	2.53E-05	0	0.0625	NS	0	0	NS	0	0	NS
AMR	0	0.0541	1.66E-04	0	0.0533	NS	0	0	NS	0	0	NS
EAS	1	0	0	0	0.0237	NS	1	0	0	0	0	NS
EUR	0	0.8738	9.47E-177	0	0.8605	6.30E-62	0	1	0	0	1	1.26E-178
SAS	0	0.0087	NS	1	0	3.93E-183	0	0	NS	1	0	1.26E-178
Select pathogenic genomic alterations
ARID1A	0.1902	0.2477	NS	0.2838	0.2460	NS	0.1902	0.2558	NS	0.2838	0.2558	NS
BRCA1	0.0293	0.0201	NS	0.0405	0.0201	NS	0.0293	0.0195	NS	0.0405	0.0195	NS
BRCA2	0.0244	0.0307	NS	0.0270	0.0306	NS	0.0244	0.0308	NS	0.0270	0.0308	NS
CD274	0.0000	0.0095	NS	0.0000	0.0094	NS	0.0000	0.0089	NS	0.0000	0.0089	NS
CDKN2A	0.4146	0.3697	NS	0.3378	0.3710	NS	0.4146	0.3666	NS	0.3378	0.3666	NS
CDKN2B	0.3463	0.2944	NS	0.2703	0.2958	NS	0.3463	0.2917	NS	0.2703	0.2917	NS
ERBB2	0.1756	0.1678	NS	0.1216	0.1684	NS	0.1756	0.1685	NS	0.1216	0.1685	NS
FGFR3	0.1659	0.1843	NS	0.0946	0.1847	NS	0.1659	0.1837	NS	0.0946	0.1837	NS
MDM2	0.0829	0.0922	NS	0.0946	0.0920	NS	0.0829	0.0923	NS	0.0946	0.0923	NS
MTAP	0.2195	0.1835	NS	0.1622	0.1845	NS	0.2195	0.1805	NS	0.1622	0.1805	NS
PIK3CA	0.1268	0.2212	5.04E-03	0.1757	0.2193	NS	0.1268	0.2209	7.46E-03	0.1757	0.2209	NS
PTEN	0.0439	0.0456	NS	0.0135	0.0459	NS	0.0439	0.0457	NS	0.0135	0.0457	NS
RB1	0.1756	0.2127	NS	0.1892	0.2120	NS	0.1756	0.2130	NS	0.1892	0.2130	NS
TERT	0.5415	0.7292	2.31E-07	0.5811	0.7260	NS	0.5415	0.7360	6.34E-08	0.5811	0.7360	NS
TP53	0.5902	0.5980	NS	0.6757	0.5972	NS	0.5902	0.5978	NS	0.6757	0.5978	NS
TSC1	0.0976	0.0874	NS	0.0676	0.0878	NS	0.0976	0.0927	NS	0.0676	0.0927	NS
Microsatellite instability (MSI)
n	198	8231	—	71	8358	—	198	7175	—	71	7175	—
MSI-high	0.0152	0.0085	NS	0.0000	0.0087	NS	0.0152	0.0088	NS	0.0000	0.0088	NS
Tumor mutational burden (TMB)
n	205	8523	—	74	8654	—	205	7447	—	74	7447	—
TMB≥10	0.3073	0.3453	NS	0.3919	0.3440	NS	0.3073	0.3489	NS	0.3919	0.3489	NS
TMB≥20	0.0732	0.1235	NS	0.1216	0.1224	NS	0.0732	0.1258	NS	0.1216	0.1258	NS
Mutational signatures
n	95	3828	—	41	3882	—	95	3368	—	41	3368	—
Alkylating	0.0105	0.0010	NS	0.0000	0.0013	NS	0.0105	0.0012	NS	0.0000	0.0012	NS
APOBEC	0.6316	0.7194	NS	0.6829	0.7177	NS	0.6316	0.7301	NS	0.6829	0.7301	NS
MMR	0.0737	0.0387	NS	0.0244	0.0397	NS	0.0737	0.0377	NS	0.0244	0.0377	NS
POLE	0.0000	0.0010	NS	0.0000	0.0010	NS	0.0000	0.0009	NS	0.0000	0.0009	NS
Tobacco	0.0000	0.0052	NS	0.0000	0.0052	NS	0.0000	0.0045	NS	0.0000	0.0045	NS
UV	0.0000	0.0146	NS	0.0000	0.0144	NS	0.0000	0.0157	NS	0.0000	0.0157	NS
PD-L1 IHC
n	3	200	—	2	201	—	3	166	—	2	166	—
PD-L1 neg	0.3333	0.6050	NS	0.5000	0.6020	NS	0.3333	0.6084	NS	0.5000	0.6084	NS
PD-L1 low	0.0000	0.2300	NS	0.5000	0.2239	NS	0.0000	0.2229	NS	0.5000	0.2229	NS
PD-L1 high	0.6667	0.1650	NS	0.0000	0.1741	NS	0.6667	0.1687	NS	0.0000	0.1687	NS

Comparisons between EAS vs. non-EAS, SAS vs. non-EAS, EAS vs. EUR, and SAS vs. EUR are shown.

^†False discovery rate (FDR) corrected using the Benjamini-Hochberg procedure.

Abbreviation: NS, not significant; SAS, South Asian; EAS, East Asian; GA, genomic alteration; EUR, European genomic ancestry; AFR, African genomic ancestry; AMR, Admixed-American genomic ancestry.