TABLE 4.

Routine investigations to be performed on the exposed individual.

Test	Baseline	6 weeks	3 months
HIV	Rapid test plus 4th-generation HIV ELISA	4th-generation HIV ELISA	4th-generation HIV ELISA†
	If child < 2 years of age: qualitative HIV PCR	If child < 2 years of age: qualitative HIV PCR	If child < 2 years of age: qualitative HIV PCR
HBV	HBsAb‡	-	HBsAg‡
HCV	HCV Ab§	HCV PCR§	-
Syphilis	If sexual exposure or source positive for syphilis, TP Ab/RPR	-	TP Ab/RPR¶
Creatinine	If TDF part of PEP	-	-
FBC and differential¶	In child if zidovudine prescribed as PEP	-	-
Pregnancy (if appropriate)††	βHCG	βHCG	-

ELISA, enzyme-linked immunosorbent assay; HBV, hepatitis B virus; HBsAb, hepatitis B surface antibody; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; HCV Ab, hepatitis C virus antibody; PCR, polymerase chain reaction; TP Ab, Treponema pallidum antibody; RPR, rapid plasma regain; FBC, full blood count; TDF, tenofovir disoproxil fumarate; PEP, post-exposure prophylaxis.

^†5th-generation ELISA may also be used.

^‡Can be omitted if exposed individual is known to be immune to HBV (through infection or vaccination).

^§Only if source is HCV Ab positive or unknown and at high risk of HCV infection.

^¶Repeat after 2 and 4 weeks in child on zidovudine.

^††In adolescents, this should be done if individual is Tanner stage 3 or greater.