TABLE 3.

Inhibition of HIV-1 RT in vitro by DCQAs with a heteropolymeric template^a

Compound	% Inhibition of HIV-1 RT with a heteropolymeric template at compound concentrations of:
	50 μg/ml	5 μg/ml	0.5 μg/ml
H2O	0	0	0
Caffeic acid	25	NTb	NT
Chlorogenic acid	−9	NT	NT
1,5-DCQA	26	13	−15
1-MO-3,5-DCQA	88	56	−17
3,5-DCQA	45	18	−1
4,5-DCQA	50	17	13
3,4-DCQA	49	21	−3
l-CCA	89	45	0

^aInhibition of HIV-1 RT activity was measured in a nonradioactive reaction against a heteropolymeric RNA template with a kit available from DuPont and tested according to the manufacturer’s instructions. Each value represents the mean inhibition of triplicate reactions. 

^bNT, not tested.