Table 2. A2B1-downregulated miRNA predicted to target the 3’UTR of PHGDH mRNA.
Using mirDIP 4.1 prediction tools we identified human miRNAs downregulated in MCF-7 cells overexpressing A2B1 (miRNA-seq. FC > 0.50, p-value <0.05). The miRNA selected are predicted to bind to the MRE in the 3’UTR of PHGDH mRNA with very high, high, or medium confidence. Also shown are the integration score, number of sources that identify PHGDH as a target of corresponding miRNA, and the sources that have identified the relationship.
| miRNA | hr post TF | logFC | P value | Integration score | # of Sources | Score Class | Sources |
|---|---|---|---|---|---|---|---|
| miR-34b-5p | 48 | −2.20 | 2.90E-02 | 0.38 | 11 | High | bitargeting_May_2021|DIANA|MirAncesTar|miranda_May_2021|mirbase|mirmap_May_2021|MiRNATIP|miRTar2GO|PITA_May_2021|RNA22|rnahybrid_May_2021 |
| miR-6801–5p | 72 | −3.01 | 1.42E-06 | 0.20 | 8 | High | bitargeting_May_2021|MirAncesTar|miranda_May_2021|mirmap_May_2021|mirzag|PITA_May_2021|RNA22|rnahybrid_May_2021 |
| miR-937–3p | 48 | −2.17 | 3.69E-02 | 0.21 | 6 | High | BCmicrO|bitargeting_May_2021|MirAncesTar|miranda_May_2021|miRTar2GO|PITA_May_2021 |
| miR-150–5p | 72 | −2.83 | 2.39E-02 | 0.22 | 9 | Medium | BCmicrO|bitargeting_May_2021|DIANA|MirAncesTar|miranda_May_2021|miRcode|mirCoX|mirmap_May_2021|RNA22 |
| miR-34c-5p | 48 | −2.36 | 8.62E-03 | 0.27 | 6 | Medium | BCmicrO|MirAncesTar|miranda_May_2021|mirbase|miRTar2GO|RNA22 |
| miR-876–5p | 72 | −3.05 | 1.83E-02 | 0.19 | 6 | Medium | BCmicrO|DIANA|MirAncesTar|mirbase|mirzag|RNA22 |
| miR-193a-3p | 48 | −0.82 | 1.72E-02 | 0.14 | 4 | Medium | BCmicrO|bitargeting_May_2021|miranda_May_2021|miRcode |
| miR-5088–5p | 72 | −2.95 | 1.80E-02 | 0.13 | 6 | Medium | bitargeting_May_2021|MirAncesTar|miranda_May_2021|mirmap_May_2021|MiRNATIP|RNA22 |
| miR-3663–5p | 48 | −2.96 | 2.38E-02 | 0.09 | 5 | Medium | bitargeting_May_2021|MirAncesTar|miranda_May_2021|MiRNATIP|RNA22 |
| miR-518d-5p | 48 & 72 | −2.37 | 4.98E-02 | 0.09 | 4 | Medium | BCmicrO|mirbase|mirmap_May_2021|RNA22 |
| miR-6789–5p | 72 | −3.05 | 5.93E-03 | 0.09 | 5 | Medium | bitargeting_May_2021|MirAncesTar|mirmap_May_2021|PITA_May_2021|RNA22 |
| miR-6794–3p | 48 | −2.57 | 4.35E-02 | 0.09 | 5 | Medium | bitargeting_May_2021|MirAncesTar|MiRNATIP|PITA_May_2021|RNA22 |
| miR-1271–3p | 72 | −3.37 | 2.15E-03 | 0.08 | 4 | Medium | bitargeting_May_2021|MirAncesTar|miranda_May_2021|RNA22 |
| miR-5682 | 48 | −2.37 | 4.98E-02 | 0.07 | 4 | Medium | bitargeting_May_2021|MirAncesTar|miranda_May_2021|RNA22 |
| miR-6733–3p | 48 | −1.74 | 3.49E-02 | 0.06 | 3 | Medium | bitargeting_May_2021|MirAncesTar|RNA22 |
| miR-6856–3p | 72 | −3.38 | 1.74E-03 | 0.06 | 3 | Medium | MirAncesTar|miranda_May_2021|mirmap_May_2021 |
| miR-4767 | 48 | −1.63 | 3.97E-02 | 0.06 | 4 | Medium | MirAncesTar|mirmap_May_2021|PITA_May_2021|RNA22 |
| miR-7975 | 48 | −2.00 | 1.86E-02 | 0.06 | 3 | Medium | bitargeting_May_2021|miranda_May_2021|RNA22 |
| miR-6872–5p | 72 | −2.86 | 1.28E-03 | 0.04 | 2 | Medium | bitargeting_May_2021|RNA22 |