Table 3. Summary of competing endogenous RNA (ceRNA) interactions with miR-145–5p, miR-424–5p, miR-34b-5p, or miR-876–5p in various types of cancer.
The table summarizes evidence of ceRNAs and their respective interactions with miR-145–5p, miR-424–5p, miR-34b-5p, or miR-876–5p in cancer. Two databases were searched for ceRNA expression in breast cancer cell lines (LncExpDB - https://ngdc.cncb.ac.cn/lncexpdb/ and circBase - http://www.circbase.org/cgi-bin/simplesearch.cgi).
| miRNA | Evidence of ceRNA activity by lncRNA or circRNA | ceRNA Expressed in Breast Cancer cell lines (database) |
|---|---|---|
| miR-145–5p | CircZNF609 acted as ceRNA of miR-145–5p in MCF-7 and MDA-MB-231 cells, upregulating the expression of oncogene p70S6K1 expression and increasing cell proliferation (Wang, et al. 2018). | |
| CircZNF236 absorbed miR-145–5p in SCC-15 and CAL-27 and increased proliferation, invasion, and migration of oral squamous cell carcinoma (OSCC) cells (Lu, et al. 2023). | (circBASE) | |
| circGOLPH3 was upregulated in OSCC cells and bound miR-145–5p, decreased its abundance and prevented miR-145–5p suppression of KDM2A which promotes tumorigenesis and metastasis (Cheng, et al. 2023). | ||
| Circ_0015756 indirectly regulated PSAT1 by binding miR-145–5p resulting in increased migration and invasion of ovarian cancer (OC) cells (Pan, et al. 2022). | ||
| Circ0001955 was increased in a genome-wide study of colorectal cancer (CRC) patients and was negatively correlated with miR-145–5p (Kadkhoda, et al. 2022). | ||
| Circ 0058063 is increased in OSCC cells and bound to miR-145–5p, upregulating the downstream target SERPIN1, contributing to cancer cell proliferation (Yu, et al. 2022) | ||
| circMYOF bound to miR-145–5p, and prevented the inhibition by miR-145–5p of OTX1 in the exosomes of laryngeal squamous cell carcinoma (LSCC) patients, increasing cell migration and invasion ability (Li, et al. 2022). | (circBase) | |
| LncRNA PVT1 acted as ceRNA of miR-145–5p in MDA-MB-231 cells and enhanced glycolysis and cell proliferation (Qu, et al. 2023) | (LncExpDB) | |
| miR-424–5p | LncRNA HCG28 inhibited miR-424–5p suppression of SOX9 expression in cholangiocarcinoma tissues and cell lines which increased cell proliferation (Ni, et al. 2023). | (LncExpDB) |
| Circ-HSP90A upregulated PD-L1 by binding to miR-424–5p and reduced the effects of immunotherapy in non-small cell lung cancer (NSCLC) cells (Lei, et al. 2023). | ||
| Depletion of circRBMS3, which regulated eIF4B and YRDC by acting as ceRNA of miR-424–5p, inhibited malignancy in an osteosarcoma xenograft mouse model (Gong, et al. 2023). | ||
| The upregulation of lncRNA AGAP2-AS1 targeted and reduced miR-424–5p in keratinocytes, leading to an upregulation of miR-424–5p target AKT3 and activation of the AKT/mTOR pathway in keratinocyte proliferation (Xian, et al. 2022). | (LncExpDB) | |
| circACTN4 (circ_0050898) acted as ceRNA of miR-424–5p in an intrahepatic cholangiocarcinoma (ICC) xenograft mouse model, increasing YAP1, a miR-424–5p target and activated Wnt/β-catenin signaling (Chen, et al. 2022). | ||
| LINC00355 induced EMT in bladder cancer cells by inhibiting miR-424–5p which increased HMGA2 expression (Li, et al. 2021). | (LncExpDB) | |
| miR-34b-5p | lncRNA SNHG3, upregulated in CRC patients, sponged miR-34b-5p in CRC cells which increased miR-34b-5p target HuR. Depleting lncRNA SNHG3 abundance inhibited cell proliferation (Zhao, et al. 2022). | (LncExpDB) |
| lncRNA OIP5-AS1, which is elevated in colon cancer (CC), targeted and inhibited miR-34b-5p in CC cells, preventing miR inhibition of HuR expression and driving CC malignancy (Wang, et al. 2022). | (LncExpDB) | |
| High expression of lncRNA PVT1 in diffuse large B-cell lymphoma (DLBCL) patients correlated to poor prognosis. lncPVT1 acted as ceRNA of miR-34b-5p in BLBCL cells, increasing Foxp. Compared to non-transfected tumor cells, cells with shRNA knockdown of PVT1 injected into mice resulted in slower tumor growth (Tao, et al. 2022) | (LncExpDB) | |
| Upregulation of LINC00355 increased ABCB1 by inhibiting miR-34b-5p in bladder cancer cells which promoted bladder cancer cell resistance to cisplatin (Luo, et al. 2021). | (LncExpDB) | |
| LINC02418 inhibited miR-34–5p suppression of BCL2 in CRC cells, promoting cell proliferation (Tian, et al. 2020). | (LncExpDB) | |
| circBFAR acted as a ceRNA of mir-34b-5p, inhibiting its suppression of MET expression in pancreatic ductal carcinoma (PDAC) cells and promoted proliferation, migration, and invasion (Guo, et al. 2020b). | (circBASE) | |
| LncNEAT1 inhibited miR-34b-5p suppression of GL1 in DLBCL cells, and increased cell proliferation (Qian, et al. 2020). | (LncExpDB) | |
| miR-875–5p | circCDR1 acted as a ceRNA of miR-876–5p, inhibiting miR suppression of SLC7A11 in OSCC cells which induced cell proliferation, migration, and invasion (Cui, et al. 2023). | |
| circ_0001686 inhibited miR-876–5p suppression of SPIN1 in esophagus cancer cells, inhibiting apoptosis and radiosensitivity (Yu, et al. 2023). | ||
| LncRNA HOXC-AS2 decreased miR-876–5p and inhibited miR suppression of HKDC1 in endometrial cancer cells, which increased cell proliferation (Guo, et al. 2022). | (LncExpDB) | |
| ciRS-7 inhibited miR-876–5p suppression of tumor antigen MAGE-A family members in esophageal squamous cell carcinoma cells and induced cell proliferation, migration, and invasion (Sang, et al. 2018). | ||
| circRPS16 decreased miR-876–5p and inhibited miR suppression of SPINK1 in hepatocellular carcinoma (HCC) cells, which increased cell proliferation, invasion, and cell cycle (Lin, et al. 2021). | (circBASE) | |
| CircVAPA acted as ceRNA of miR-876–5p, which inhibited miR suppression of WNT5A in NSCLC cells and increased cell viability and proliferation (Zhao, et al. 2021). | (circBASE) | |
| lncRNA SNGHG14 inhibited miR-876–5p suppression of SSR2 in HCC cells which induced cell proliferation, migration, and invasion (Liao, et al. 2021). | ||
| circHIPK3 inhibited miR-875–5p suppression of PIK3R1 in gastric cancer cells and increased cell proliferation, migration, invasion, and glutaminolysis (Li, et al. 2020a). | (circBASE) | |
| LncRNA PITPNA-AS1 acted as a ceRNA of miR-875–5p, reducing miR suppression of c-MET in cervical cancer cells and increased cell proliferation and cell cycle (Guo, et al. 2020a). | (LncExpDB) | |
| MCM3AP-AS1 acted as a ceRNA of miR-876–5p, reducing miR suppression of WNT5A in prostate cancer cells, which increased cell proliferation (Wu, et al. 2020). | (LncExpDB) | |
| lncRNA MINCR inhibited miR-876–5p suppression of GSPT1 in glioma cells and increased cell migration and invasion (Li, et al. 2020b). | (LncExpDB) | |
| LncRNA PITPNA-AS1 acted as a ceRNA of miR-875–5p, reducing miR suppression of WNT5a in HCC cells and promoted EMT (Sun, et al. 2019). | (LncExpDB) | |
| LncRNA HOXC-AS2 decreased miR-876–5p and inhibited miR suppression of ZEB in glioma cells, which increased EMT (Dong, et al. 2019). | (LncExpDB) |
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Gong Z, Shen P, Wang H, Zhu J, Liang K, Wang K, Mi Y, Shen S, Fang X & Liu G 2023 A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis. Aging (Albany NY) 15 1564–1590.
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Lei J, Zhu J, Hui B, Jia C, Yan X, Jiang T & Wang X 2023 Circ-HSP90A expedites cell growth, stemness, and immune evasion in non-small cell lung cancer by regulating STAT3 signaling and PD-1/PD-L1 checkpoint. Cancer Immunology, Immunotherapy 72 101–124.
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Li S, Zhang Y, He Z, Xu Q, Li C & Xu B 2022 Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145–5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma. Functional & Integrative Genomics 22 1–13.
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Li Z, Xie X, Fan X & Li X 2020b Long Non-coding RNA MINCR Regulates miR-876–5p/GSPT1 Axis to Aggravate Glioma Progression. Neurochemical Research 45 1690–1699.
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Ni Q, Zhang H, Shi X & Li X 2023 Exosomal lncRNA HCG18 contributes to cholangiocarcinoma growth and metastasis through mediating miR-424–5p/SOX9 axis through PI3K/AKT pathway. Cancer Gene Ther 30 582–595.
Pan Y, Huang Q, Peng X, Yu S & Liu N 2022 Circ_0015756 promotes ovarian cancer progression via the miR-145–5p/PSAT1 axis. Reprod Biol 22 100702.
Qian CS, Li LJ, Huang HW, Yang HF & Wu DP 2020 MYC-regulated lncRNA NEAT1 promotes B cell proliferation and lymphomagenesis via the miR-34b-5p-GLI1 pathway in diffuse large B-cell lymphoma. Cancer Cell Int 20 87.
Qu H, Li X, Chen F, Zhang M, Lu X, Gu Y, Lv M & Lu C 2023 LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145–5p. Genes Genomics 45 581–592.
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Xian J, Shang M, Dai Y, Wang Q, Long X, Li J, Cai Y, Xia C & Peng X 2022 N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424–5p/AKT3 axis. J Dermatol Sci 105 27–36.
Yu J, Lou Y, Hou M, Ma X & Wang L 2022 Circ_0058063 contributes to oral squamous cell carcinoma development by sponging miR-145–5p and upregulating SERPINE1. J Oral Pathol Med 51 630–637.
Yu W, Ning K, Bai Q & Xiao J 2023 Circ_0001686 knockdown suppresses tumorigenesis and enhances radiosensitivity in esophagus cancer through regulating miR-876–5p/SPIN1 axis. Pathol Res Pract 241 154216.
Zhao J, Lin H, Huang K & Li S 2022 Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p/HuR/HOXC6 axis. Cell Death Discov 8 346.
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