Table 3.
Immunohistochemical differential diagnosis of secretory carcinoma
| Parameters | CK7 | p63 | p40 | S100 | SOX10 | DOG1 | MG | SMA | PLAG1 | Pan-TRK |
|---|---|---|---|---|---|---|---|---|---|---|
| Secretory carcinoma | + | – | – | + | + | – | + | – | – | +/ – |
| Mucoepidermoid carcinoma | +/ – | + | + | – | – | – | –/+ | – | – | – |
| Acinic cell carcinoma | + | – | – | – | + | + | – | – | – | – |
| Polymorphous carcinoma | + | + | – | + | + | – | +/ – | – | – | – |
| Adenocarcinoma NOS | + | – | – | – | – | – | –/+ | – | – | – |
| Microsecretory adenocarcinoma | – | + | – | + | + | – | – | –/+ | – | – |
| Myoepithelial carcinoma | – | + | + | + | + | – | – | + | –/+ | v |
| Pleomorphic adenoma | + (LC) |
+ (MC) |
+ (MC) |
+ (MC) |
+ (MC) |
– (MC) |
– (MC) |
+ (MC) |
+/ – | – |
LC – luminal cells, MC – myoepithelial cells, MG – mammaglobin