TABLE 4.
Tissue counts for mice infected with 9 × 105 CFU of C. albicans per mouse, treated from day 1 through 6 with amphotericin B or KY-62, and sacrificed on day 8a
| Tissue and treatment group | n | CFU/g
|
|
|---|---|---|---|
| Median | Range | ||
| Spleen | |||
| Control | 7 | 7.4 | 0.2–53 |
| Amphotericin B, 1 mg/kg | 7 | <0.2b | |
| KY-62, 30 mg/kg | 7 | <0.2b | |
| Kidneys | |||
| Control | 7 | 70.0 | 5.8–210 |
| Amphotericin B, 1 mg/kg | 7 | 0.002b | 0.002–0.28 |
| KY-62, 30 mg/kg | 7 | <0.0002b | <0.0002–0.10 |
a
n, number of mice per group. Spleen values are expressed as 103 CFU/g; kidney values are expressed as 105 CFU/g. The minimal detectable colony count was approximately 20 CFU/g. Subthreshold values were arbitrarily given a count of 20 CFU/g.
b
Counts significantly less than those of controls.