TABLE 5.
Survival of neutropenic mice after i.v. infection with 3 × 105 CFU of C. albicans per mouse and treatment from day 1 through 10 with amphotericin B or KY-62, given i.v. or i.p.
| Treatment (mg/kg) | i.v.
|
i.p.
|
||||
|---|---|---|---|---|---|---|
| nb | Survivala
|
nb | Survivala
|
|||
| Mean | SEM | Mean | SEM | |||
| Control (0) | 10 | 8.0 | 2.7 | |||
| Amphotericin B (1) | 10 | 25.5c | 3.7 | |||
| Amphotericin B (5) | 10 | 10 | 17.5 | 4.5 | ||
| KY-62 (1) | 9 | 10.9 | 3.8 | 9 | 7.1 | 2.7 |
| KY-62 (5) | 10 | 13.6c | 3.8 | 10 | 6.9 | 0.6 |
| KY-62 (10) | 9 | 16.9c | 4.5 | 9 | 5.8 | 0.5 |
| KY-62 (20) | 10 | 10.9 | 3.4 | 10 | 11.0 | 3.3 |
| KY-62 (30) | 10 | 7.2d | 2.7 | 10 | 8.7 | 2.5 |
a
Survival is expressed as number of days after infection (mean ± standard error of the mean).
b
n, number of mice per group.
c
Survival significantly longer than that of controls.
d
Two mice died immediately after receiving the first dose.