TABLE 6.
Survival of groups of 10 neutropenic mice infected i.v. with 1.7 × 106 CFU of C. albicans per mouse and treated with KY-62 i.p., flucytosine in drinking water, or botha
| Group | Survival
|
|
|---|---|---|
| Mean | SEM | |
| Control | 4.6 | 0.2 |
| KY-62, 15 mg/kg/day | 6.5 | 0.4 |
| 5FC, 60 mg/kg/day | 9.8 | 1.0 |
| KY-62 and 5FC | 14.2 | 3.7 |
| Control | 3.8 | 0.4 |
| KY-62, 30 mg/kg/day | 6.0 | 0.5 |
| 5FC, 80 mg/kg/day | 10.6 | 3.0 |
| KY-62 and 5FC | 13.0 | 3.4 |
a
Survival is expressed as number of days after infection. All groups survived longer than controls. The combination therapy group did not survive significantly longer than the flucytosine (5FC) group.