TABLE 3.

Yeast cell counts in spleens and livers of mice infected with H. capsulatum intravenously, treated from day 1 through day 7, and sacrificed on day 8 after infection^a

Mouse	Inoculum	Group	Dose (mg/kg)	Median count (106 CFU/g) ina:
				Spleen	Liver
nu/+	8 × 106	Control	0	88.2	20.6
		MK-991	10	52.7	14.0
			5 BIDb	10.9∗	3.4∗
			5	10.9∗	2.8∗
			0.5	5.8∗	3.5∗
nu/+	1 × 106	Control	0	30.3	11.4
		MK-991	10	2.8∗	1.6∗
			0.25	2.4∗	0.8∗
			0.1	3.6∗	1.6∗
			0.05	5.6∗	2.0∗
nu/nu	2 × 106	Control	0	781	377
		MK-991	5	131∗	104∗
	8 × 105	Control	0	123	127
		MK-991	5	25.6∗∗	28.0∗∗
	6 × 104	Control	0	6.3	1.3
		MK-991	5	0.9∗	0.6
	3 × 104	Control	0	11.9	2.2
		MK-991	5	3.5∗	1.2∗

^a∗, significantly different from control value. ∗∗, not significant because of two outlying low-count values. 

^bBID, twice daily.