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. 2023 Oct 3;19(10):e1011683. doi: 10.1371/journal.ppat.1011683

Fig 3. Restoration of gut microbiome alleviated helminth-induced cardiac fibrosis.

Fig 3

(A) Experimental scheme of Ts-infected mice received healthy gut microbiota. (B) Whole heart images of Ts-infected mice (Ts) (n = 6) and Ts-infected mice received healthy fecal microbiota transplantation (FMT) (Ts+FMT-H) (n = 6). Representative images are shown. (C) Heart mass-to-body weight ratio (HM/BW). (D and E) Ejection fraction (EF) and left ventricular weight (LVM) obtained by cardiac ultrasound. (F and G) qPCR analysis of Collagen-1 (Col1) and α-SMA expression in the heart tissue of mice. (H and I) Masson staining and Col1 immunohistochemistry results of heart tissues. Magnification, 200×. Scale bars, 100 μm. Representative images are shown. Data are shown as individual data points and mean ± SD. Statistical significance is calculated using paired student t-test. ns, not significant; *, p < 0.05; **, p < 0.01, ***, p <0.001, ****, p <0.0001.