Table 2:
Intradialytic variables related to RCA during CKRT.
| Variable | CKRT start | CKRT 2 h | CKRT 8 h | CKRT 12 h | CKRT 24 h | CKRT 48 h | CKRT 72 h | ANOVA | P |
|---|---|---|---|---|---|---|---|---|---|
| CVVH | |||||||||
| ACT, s | 117.1 (17.0) | 123.7 (20.0) | 122.3 (21.3) | 123.0 (28.5) | 114.7 (24.0) | 114.3 (17.3) | 109.6 (17.4) | F(2.51, 20.12) = 2.38 | .108 |
| s-Ca2+, mmol/L* | 1.07 (0.17) | 0.99 (0.15) | 1.15 (0.12) | 1.24 (0.13) | 1.28 (0.12) | 1.17 (0.06) | 1.19 (0.09) | F(6, 54) = 7.08 | <.001 |
| c-Ca2+, mmol/L | NA | 0.38 (0.08) | NA | NA | NA | NA | NA | NA | NA |
| CaCl2, mL/h* | 5.43 (0.34) | 6.90 (1.12) | 8.22 (2.67) | 7.79 (2.75) | 5.81 (1.67) | 5.87 (0.98) | 5.86 (1.41) | F(2.08, 18.70) = 5.33 | .014 |
| HCO3−, mmol/L* | 20.7 (4.2) | 21.0 (3.6) | 21.6 (3.2) | 22.3 (3.1) | 22.8 (2.0) | 24.0 (1.8) | 24.8 (2.3) | F(1.46, 13.11) = 5.46 | .026 |
| Lactate, mmol/L | 0.95 (0.37) | 1.03 (0.42) | NA | NA | NA | NA | NA | NA | .458 |
| Citrate, mmol/L* | 0.65 (0.30) | 0.75 (0.22) | 0.90 (0.37) | 1.07 (0.46) | 1.02 (0.46) | 0.82 (0.31) | 0.96 (0.35) | F(6, 30) = 2.902 | .024 |
| CVVHDF | |||||||||
| ACT, s | 114.2 (14.6) | 109.8 (7.8) | 113.3 (12.5) | 109.3 (16.5) | 116.7 (12.8) | 110.8 (5.8) | 113.7 (8.4) | F(6, 30) = 0.576 | .747 |
| s-Ca2+, mmol/L* | 1.10 (0.08) | 1.06 (0.09) | 1.15 (0.07) | 1.20 (0.08) | 1.18 (0.08) | 1.12 (0.06) | 1.17 (0.07) | F(6, 48) = 4.128 | .002 |
| c-Ca2+, mmol/L | NA | 0.41 (0.11) | NA | NA | NA | NA | NA | NA | NA |
| CaCl2, mL/h | 5.49 (1.86) | 6.21 (2.00) | 7.30 (2.11) | 6.52 (1.83)** | 6.00 (1.07) | 5.64 (1.26) | 5.44 (0.60) | F(6, 48) = 3.027 | .014 |
| HCO3−, mmol/L | 25.5 (4.9) | 24.5 (4.5) | 24.2 (4.9) | 24.3 (4.2) | 25.0 (3.4) | 24.9 (3.0) | 25.3 (2.8) | F(1.76, 14.05) = 0.506 | .59 |
| Lactate, mmol/L | 1.08 (0.42) | 1.13 (0.43) | NA | NA | NA | NA | NA | NA | .839 |
| Citrate, mmol/L | 0.42 ± 0.14 | 0.52 ± 0.24 | 0.53 ± 0.19 | 0.52 ± 0.17 | 0.63 ± 0.24 | 0.63 ± 0.23 | 0.56 ± 0.37 | F(2.44, 14.6) = 1.5 | .257 |
*No difference between time points at the pairwise analysis; **P < .05 in comparison with baseline
Data are presented as mean (SD). Values are intended as measured on patients’ blood if not otherwise indicated. P-values refer to test for trend across all the available sample times.
ACT, activated clotting time; s-Ca2+, systemic ionized calcium; c-Ca2+, circuit ionized calcium; CaCl2, calcium chloride infusion; HCO3−, bicarbonate; NA, not available.