TABLE 3.
Effect of each DHFR point mutation irrespective of the other two on PM and CCG IC50s for Kenyan P. falciparum field isolates
| DHFR genotype | IC50a for isolates with mutation at codon (n)
|
|||||
|---|---|---|---|---|---|---|
| 108
|
51
|
59
|
||||
| PM | CCG | PM | CCG | PM | CCG | |
| Wild type | 3.71 ± 6.94 (5) | 0.24 ± 0.20 (5) | 66.20 ± 68.60 (24) | 1.46 ± 2.30 (24) | 34.70 ± 44.21 (15) | 1.178 ± 1.43 (15) |
| Mixed alleles | 97.52 ± 99.70 (24) | 2.28 ± 2.20 (24) | 140.18 ± 83.63 (21) | 2.38 ± 1.71 (21) | 148.11 ± 96.10 (12) | 2.52 ± 2.26 (12) |
| Mutated alleles | 447.60 ± 515.09 (40) | 6.00 ± 6.57 (40) | 646.18 ± 588.98 (24) | 8.68 ± 7.23 (24) | 427.74 ± 511.42 (42) | 5.91 ± 6.47 (42) |
a
IC50s are in nanomolar concentrations; P < 0.01 for each group compared with the other two.