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. 2023 Aug 3;25(10):1895–1909. doi: 10.1093/neuonc/noad124

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Secondary radiation-induced gliomas (RIGs) originate de novo from the glial cell lineage and not from the original primary tumor. (A) Unsupervised hierarchical clustering of batch-effect adjusted RNA-seq profiles from primary medulloblastoma and secondary RIG tumors (based on top 500 HVGs). (B) UMAP visualization of medulloblastoma and glioblastomas. Primary medulloblastoma and corresponding secondary RIGs are marked with circles. (C) Comparison of gene expression profiles of primary medulloblastoma and secondary RIG tumors combined with corresponding FFPE bulk control to cerebellum cell state, based on correlation measures.