Table.
Baseline characteristics of WGS and all syphilis diagnoses from GUMCAD in England, 2012–18
| Whole genome sequencing (n=237) | All syphilis diagnoses (n=50 845) | |
|---|---|---|
| Year | ||
| 2012 | 21 (8·9%) | 4856 (9·6%) |
| 2013 | 19 (8·0%) | 5308 (10·4%) |
| 2014 | 12 (5·1%) | 6342 (12·5%) |
| 2015 | 38 (16·0%) | 7351 (14·5%) |
| 2016 | 71 (30·0%) | 8034 (15·8%) |
| 2017 | 48 (20·3%) | 9177 (18·0%) |
| 2018 | 28 (11·8%) | 9777 (19·2%) |
| Self-identified gender | ||
| Male | 220 (92·8%) | 42 168 (82·9%) |
| Female | 9 (3·8%) | 6467 (12·7%) |
| Unknown | 8 (3·4%) | 2210 (4·3%) |
| Gender orientation | ||
| MSW | 25 (10·5%) | 8978 (17·7%) |
| GBMSM | 180 (75·9%) | 33 190 (65·3%) |
| WSM | 9 (3·8%) | 6467 (12·7%) |
| Men with unrecorded sexual orientation | 15 (6·3%) | .. |
| Unknown | 8 (3·4%) | 2210 (4·4%) |
| Age group | ||
| 16–24 years | 30 (12·7%) | 6194 (12·2%) |
| 25–34 years | 70 (29·5%) | 16 298 (32·1%) |
| 35–44 years | 59 (24·9%) | 13 487 (26·5%) |
| ≥45 years | 76 (32·1%) | 14 671 (28·9%) |
| Unknown | 2 (0·8%) | 195 (0·4%) |
| Region of residence | ||
| East Midlands | 5 (2·1%) | 2398 (4·7%) |
| East of England | 8 (3·4%) | 2495 (4·9%) |
| London | 118 (49·8%) | 24 326 (47·8%) |
| Northeast | 24 (10·1%) | 1497 (2·9%) |
| Northwest | 6 (2·5%) | 5079 (9·5%) |
| Southeast | 29 (12·2%) | 4776 (9·4%) |
| Southwest | 15 (6·3%) | 2082 (4·1%) |
| West Midlands | 7 (3·0%) | 3763 (7·4%) |
| Yorkshire & Humber | 5 (2·1%) | 2760 (5·4%) |
| Unknown | 18 (7·6%) | 1475 (2·9%) |
| UK (not England) | 2 (0·8%) | 194 (0·4%) |
| UK birth status | ||
| Non-UK born | 66 (27·8%) | 24 191 (47·6%) |
| UK born | 138 (58·2%) | 26 654 (52·4%) |
| Unknown | 33 (13·9%) | .. |
| HIV status (GBMSM only)* | ||
| Negative | 121 (51·1%) | 21 888 (43·1%) |
| Positive | 65 (27·4%) | 11 302 (22·2%) |
| Data unavailable | 51 (21·5%) | 17 655 (34·7%) |
| Syphilis stage (matched to diagnoses only, n=140†) | ||
| Primary | 114 (81·4%) | 14 178 (27·9%) |
| Secondary | 15 (10·7%) | 9918 (19·5%) |
| Early latent | 10 (7·1%) | 12 261 (24·1%) |
| Late latent | 1 (0·7%) | 13 032 (25·6%) |
| Cardio | 0 | 635 (1·3%) |
| Neuro | 0 | 821 (1·6%) |
Gender categories are based on reported sexual orientation and gender identity, not on behaviours. WGS=whole genome sequencing. GUMCAD=Genitourinary Medicine Clinic Activity Dataset. MSW=men who have sex with women. GBMSM=gay, bisexual, and other men who have sex with men. WSM=women who have sex with men.
*
All diagnoses: n=33 190; WGS: n=186.
†
WGS dataset only.