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. 2023 Oct 3;14:5962. doi: 10.1038/s41467-023-41231-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Each panel (a), (b), (c) and (d) is listed in chronological order of the analysis procedure. a Schematic MR diagram. b MR scatter plot. c Selection of candidate traits for inclusion into MVMR via PheWAS findings. d Modelling the candidate traits into the MVMR analysis to obtain the marginal effect of MPB on skin cancer risk, by conditioning on endogenous testosterone levels and other candidate traits.