. 2023 Oct 3;14:5962. doi: 10.1038/s41467-023-41231-8

Table 2.

Validation of MR association between risk factors and skin cancer risk using SNP instruments derived from independent non-overlapping subset of UKB

Cancer outcome	Risk factors	With all SNP instruments identified from entire UKB cohort						With only SNP instruments that has p < 1e−5 in independent UKB dataset
Cancer outcome	Risk factors	$P_{U K B}$	$O R_{U K B}$	$P_{Q S K I N}$	$O R_{Q S K I N}$	$P_{M E T A}$	$O R_{M E T A}$	$P_{U K B}$	$O R_{U K B}$	$P_{Q S K I N}$	$O R_{Q S K I N}$	$P_{M E T A}$	$O R_{M E T A}$
all KC	MPB	1.45E-04	1.17 (1.08 to 1.27)	0.78	1.03 (0.85 to 1.24)	2.94E-04	1.15 (1.06 to 1.23)	3.86E-03	1.16 (1.05 to 1.28)	0.35	1.11 (0.89 to 1.37)	2.61E-03	1.15 (1.05 to 1.26)
	TotalT	0.83	1.01 (0.93 to 1.1)	0.3	1.15 (0.88 to 1.5)	0.61	1.02 (0.94 to 1.10)	0.81	1.01 (0.93 to 1.10)	0.32	1.15 (0.87 to 1.52)	0.6	1.02 (0.94 to 1.11)
	FreeT	0.61	0.96 (0.83 to 1.12)	0.89	0.97 (0.66 to 1.44)	0.6	0.96 (0.84 to 1.11)	0.61	0.96 (0.81 to 1.13)	0.74	0.94 (0.63 to 1.39)	0.55	0.95 (0.82 to 1.11)
	SHBG	0.22	1.05 (0.97 to 1.12)	0.59	1.05 (0.88 to 1.24)	0.18	1.05 (0.98 to 1.12)	0.22	1.05 (0.97 to 1.12)	0.59	1.05 (0.88 to 1.25)	0.18	1.05 (0.98 to 1.12)
BCC	MPB	1.84E-03	1.15 (1.05 to 1.26)	0.49	1.1 (0.84 to 1.43)	1.32E-03	1.15 (1.06 to 1.25)	0.02	1.14 (1.02 to 1.28)	0.31	1.17 (0.87 to 1.58)	0.01	1.15 (1.03 to 1.27)
	TotalT	0.37	1.04 (0.95 to 1.15)	0.29	1.18 (0.86 to 1.62)	0.25	1.06 (0.96 to 1.15)	0.45	1.04 (0.94 to 1.15)	0.5	1.12 (0.81 to 1.55)	0.36	1.05 (0.95 to 1.15)
	FreeT	0.85	0.98 (0.83 to 1.16)	0.75	0.93 (0.57 to 1.5)	0.78	0.98 (0.84 to 1.14)	0.77	0.97 (0.81 to 1.17)	0.54	0.87 (0.55 to 1.37)	0.62	0.96 (0.81 to 1.14)
	SHBG	0.13	1.07 (0.98 to 1.16)	0.39	1.11 (0.88 to 1.39)	0.08	1.07 (0.99 to 1.15)	0.12	1.07 (0.98 to 1.16)	0.35	1.11 (0.89 to 1.40)	0.08	1.07 (0.99 to 1.16)
SCC	MPB	2.35E-06	1.31 (1.17 to 1.46)	0.65	1.08 (0.77 to 1.53)	4.25E-06	1.28 (1.15 to 1.43)	1.33E-04	1.29 (1.13 to 1.48)	0.48	1.15 (0.77 to 1.72)	1.19E-04	1.28 (1.13 to 1.45)
	TotalT	0.24	0.92 (0.81 to 1.05)	0.31	1.24 (0.82 to 1.87)	0.41	0.95 (0.84 to 1.08)	0.49	0.95 (0.83 to 1.09)	0.42	1.19 (0.77 to 1.84)	0.68	0.97 (0.85 to 1.11)
	FreeT	0.46	0.92 (0.75 to 1.14)	0.82	1.07 (0.58 to 1.99)	0.54	0.94 (0.77 to 1.15)	0.59	0.94 (0.77 to 1.16)	0.79	1.09 (0.57 to 2.09)	0.67	0.96 (0.78 to 1.17)
	SHBG	0.92	0.99 (0.9 to 1.1)	0.99	1.00 (0.74 to 1.36)	0.93	1.00 (0.90 to 1.10)	0.86	0.99 (0.90 to 1.10)	0.96	1.01 (0.74 to 1.37)	0.88	0.99 (0.90 to 1.09)
Melanoma	MPB	–	–	–	–	0.84	0.99 (0.91 to 1.08)	–	–	–	–	0.38	0.96 (0.88 to 1.05)
	TotalT	–	–	–	–	0.29	0.94 (0.84 to 1.05)	–	–	–	–	0.34	0.94 (0.84 to 1.06)
	FreeT	–	–	–	–	0.91	0.99 (0.81 to 1.20)	–	–	–	–	0.84	0.98 (0.78 to 1.22)
	SHBG	–	–	–	–	0.22	0.95 (0.88 to 1.03)	–	–	–	–	0.25	0.95 (0.88 to 1.03)