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. 2022 Nov 30;13(10):4105–4126. doi: 10.1016/j.apsb.2022.11.026

Figure 3.

Figure 3

mRNA vaccinization in vivo. (1) Construction of mRNA lipid NPs, (2) endocytosis, (3) entry into lysosome, (4) escape from lysosome, (5) recognization by (TLRs, (6) translation of replicase, (7) self-amplification of mRNA, (8) translation of antigen protein, (9) secretion of antigen protein, (10) MHC-I presentation, (11) MHC-II presentation.