Figure 3.
mRNA vaccinization in vivo. (1) Construction of mRNA lipid NPs, (2) endocytosis, (3) entry into lysosome, (4) escape from lysosome, (5) recognization by (TLRs, (6) translation of replicase, (7) self-amplification of mRNA, (8) translation of antigen protein, (9) secretion of antigen protein, (10) MHC-I presentation, (11) MHC-II presentation.