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. 2022 Nov 25;13(10):4127–4148. doi: 10.1016/j.apsb.2022.11.021

Figure 4.

Figure 4

Multiple drug delivery carriers used in cartilage DDS. (A) Construction of gelatin scaffolds encapsulated with SDF-1 and TGF-β1. Reprinted with the permission from Ref. 134. Copyright © 2019, American Chemical Society. (B) RAD and SKP peptides are immobilized to form a nanofiber hydrogel, and agomir-29b-5p is encapsulated inside the hydrogel. Reprinted with the permission from Ref. 136. Copyright © 2022, Author. (C) Construction of Zein/PLLA nanofibers loaded with BMP-2 and dexamethasone in different phases using coaxial electrospinning. Reprinted with the permission from Ref. 140. Copyright © 2018, Elsevier B.V. (D) Multilayer scaffold design loaded with BMP7, TGF-β1, and IGF-1 in different layers. Reprinted with the permission from Ref. 142. Copyright © 2022, Ivyspring International Publisher. (E) SF nanospheres with sequential release of E7/KGN from the SF porous matrix for osteochondral defect treatment. Reprinted with the permission from Ref.150. Copyright © 2020, The Authors. (F) The fabrication of MOF-coated mesoporous polydopamine loaded with Br and Rap. Reprinted with the permission from Ref.154. Copyright © 2021, The Authors. (G) SOX5, SOX6 and SOX9 were incorporated into a multicistronic plasmid and combined with the polycationic polymer polyethylenimine to induce MSC differentiation. Reprinted with the permission from Ref. 157. Copyright © 2017, American Chemical Society. Abbreviations: SDF-1α, stromal cell-derived factor 1α; TGF-β1, transforming growth factor beta 1; MSCs, mesenchymal stem cells; BSA, bovine serum albumin; BMP-2, bone morphogenetic protein 2; PLLA, poly-l-lactic acid; BMP-7, bone morphogenetic protein 7; IGF-1, insulin-like growth factor-1; HA, hydroxyapatite; Dex, dexamethasone; rap, rapamycin; Br, bilirubin; SF, silk fibroin; PVA, polyvinyl alcohol.