Figure 6.

Synergistic targeting of each catabolic and anabolic activity. (A) The crosstalk between inflammation and the immune system, matrix degradation, and chondrocyte survival is complicated. Multiple drug delivery may simultaneously target these processes to synergistically inhibit catabolic activities. (B) The chondrogenic differentiation of MSCs into mature chondrocytes involves condensation, differentiation and maturation processes. Simultaneous targeting of various processes may enhance anabolic activities and accelerate cartilage regeneration.