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. 2023 Aug 7;13(10):4202–4216. doi: 10.1016/j.apsb.2023.08.002

Figure 4.

Figure 4

Toll-like receptor 4 (TLR4) deficiency does not influence the severity of CP. (A) Intestinal permeability was assessed by measuring fluorescein isothiocyanate (FITC)-dextran (n = 6). (B) The representative macrographic images of the pancreas. (C) The ratio of pancreatic weight and body weight (n = 6). (D) The representative images and parenchyma rates of the pancreas by H&E staining (n = 6). Scale bar: 100 μm. (E) The representative images and fibrosis rates of the pancreas by Masson's Trichrome staining as indicated by collagen-rich scars (blue color) (n = 6). Scale bar: 100 μm. (F) The fibrosis-associated gene (Tgfb1, Col1, Acta2 and Fn1) expression in the pancreas (n = 6). (G) The monocyte chemoattractant protein-1 (MCP-1) levels in the pancreas (n = 6). Data (A, C–G) are representative and were the mean ± SD from three independent experiments. P values were calculated by one-way ANOVA followed by Tukey's post hoc test for multiple comparisons.