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. 2023 Aug 7;13(10):4202–4216. doi: 10.1016/j.apsb.2023.08.002

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© 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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SCFAs alleviate monocyte recruitment and pancreatic macrophage deregulation in mice with CP. (A) The MCP-1 levels in the pancreas (n = 6). (B) The frequency of Ly6C^hi C–C Motif chemokine receptor 2 (CCR2)⁺ monocytes among CD45⁺CD11b⁺ population (n = 6). (C) The frequency of CD11b⁺F4/80⁺ macrophages among CD45⁺ population (n = 6). (D) The frequency of inducible nitric oxide synthase (iNOS)⁺ M1 macrophages among CD45⁺CD11b⁺F4/80⁺ population (n = 6). (E) The frequency of F4/80⁺CD206⁺ M2 macrophages among CD45⁺CD11b⁺ population (n = 6). (F) The frequency of CCR2⁺ M2 macrophages among CD45⁺CD11b⁺ F4/80⁺CD206⁺ population (n = 6). Data (A) are representative and were the mean ± SD from three independent experiments. Data (B–F) were representative and were the median ± interquartile range from three independent experiments. P values were calculated by one-way ANOVA followed by Tukey's post hoc test for multiple comparisons.