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. 2023 Aug 7;13(10):4202–4216. doi: 10.1016/j.apsb.2023.08.002

Figure 7.

Figure 7

Oral treatment with a specific G+ SCFAs-producer Roseburia intestinalis (R. intestinalis) attenuates the severity of CP. (A) The levels of SCFAs (acetate, propionate and butyrate) in colon content (n = 6). (B) The representative images and histological scores of the colon by H&E staining (n = 6). Scale bar: 200 μm. (C) Intestinal permeability assessment by measuring FITC-dextran (n = 6). (D) The mRNA expression of antimicrobial peptides (Camp, Defb1, Defb2, Reg1 and Reg4, n = 6). (E, F) The representative macroscopic images of the pancreas (E) and the ratio of pancreatic weight and body weight (F) (n = 6). (G) The representative images and parenchyma rates of the pancreas by H&E staining (n = 6). Scale bar: 100 μm. (H) The representative images and fibrosis rates of the pancreas by Masson's Trichrome staining (n = 6). Scale bar: 100 μm. (I) The mRNA expression of markers relevant to pancreatic fibrosis (n = 6). Data (A–D and F–I) are representative and were the mean ± SD from three independent experiments. P values were calculated by one-way ANOVA followed by Tukey's post hoc test for multiple comparisons.