Table 3. Creatine phosphokinase level and liver function test results.

Variables			R20 (n=132)	RE10/10 (n=126)	p-value
After 12 wk
	Creatine phosphokinase
		>ULN	13 (9.9)	7 (5.6)	0.197*
		>4×ULN	0 (0.0)	0 (0.0)	-
		>10×ULN	0 (0.0)	0 (0.0)	-
	Liver enzymes
		AST or ALT >4×ULN	0 (0.0)	0 (0.0)	-
		AST or ALT >10×ULN	0 (0.0)	0 (0.0)	-
After 24 wk
	Creatine phosphokinase
		>ULN	16 (12.1)	10 (7.9)	0.264*
		>4×ULN	2 (1.5)	0 (0.0)	0.498†
		>10×ULN	0 (0.0)	0 (0.0)	-
	Liver enzymes
		AST or ALT >4×ULN	1 (0.8)	0 (0.0)	1.000†
		AST or ALT >10×ULN	1 (0.8)	0 (0.0)	1.000†

Values are presented as number (%).

R20, high-intensity statin group which received 20 mg of rosuvastatin once daily; RE10/10, combination therapy group which received 10 mg rosuvastatin and 10 mg ezetimibe once daily; ULN, upper limit of normal; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

^*χ² test; ^†Fisher’s exact test.