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. 2023 Sep 20;14:1268900. doi: 10.3389/fimmu.2023.1268900

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Copyright © 2023 Zeven, De Groof, Ceuppens, Awad, Ertveldt, de Mey, Meeus, Raes, Breckpot and Devoogdt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-TIGIT Nbs bind to TIGIT expressed on splenocytes or PBMCs, results from the lead Nbs are shown. (A) anti-mTIGIT Nb 16988 incubated with 900 nM to CD3/28 dynabeads-activated mouse splenocytes, compared to the irrelevant ctrl Nb R3B23 and the commercially available mAb. (B) anti-hTIGIT Nb 16925 or Vibo ScFv incubated with 900 nM to CD3/28 dynabeads-activated human PBMCs, compared to the irrelevant ctrl Nb R3B23 and the commercially available mAb. Binding of Nb or scFv was detected with PE-labeled anti-His antibody on flow cytometry.