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. 2023 Sep 20;14:1268900. doi: 10.3389/fimmu.2023.1268900

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Copyright © 2023 Zeven, De Groof, Ceuppens, Awad, Ertveldt, de Mey, Meeus, Raes, Breckpot and Devoogdt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo SPECT-CT imaging and ex vivo biodistribution of the anti-mTIGIT Nbs in immunodeficient mice bearing TC-1 tumors (n=3). (A) 3D-rendered SPECT-CT images (top) and a transversal slice at the level of the tumors (bottom) of a representative mouse bearing a mTIGIT-transduced (+) and an untransduced (-) TC-1 tumor and injected with ^99mTc-labeled anti-mTIGIT Nb 16988 (left) or control Nb R3B23 (right). (B) ex vivo biodistribution results of the control Nb and the three selected anti-mTIGIT Nbs showing percentage injected activity per gram (%IA/g) tissue in WT TC-1 and mTIGIT⁺ TC-1 tumors. Two-way ANOVA was used to calculate statistical significance. Statistical significance was set at p<0.05 (ns, not significant, ***=p<0.001, ****=p<0.0001).