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. 2023 Sep 20;14:1268900. doi: 10.3389/fimmu.2023.1268900

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Copyright © 2023 Zeven, De Groof, Ceuppens, Awad, Ertveldt, de Mey, Meeus, Raes, Breckpot and Devoogdt

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-mTIGIT Nbs show high signal-to-noise ratios compared to the control Nb R3B23. Ratios of uptake of ^99mTc-labeled anti-mTIGIT Nbs in TC-1 mTIGIT⁺ tumor to (A) TC-1 WT tumor, (B) muscle, (C) blood or to (D) liver (n=3), ratios are calculated as following: uptake in TC-1 mTIGIT⁺ divided by uptake in TC-1 WT tumor, muscle, liver, or blood. One-way ANOVA was used to evaluate statistical significance. Statistical significance was set at p<0.05 (**=p<0.01, ***=p<0.001, ****=p<0.0001).