Figure 3. Overall Hazard Ratio Forest Plot From the 2-Stage IPD Meta-Analysis for MACCEs and Individual Components.

Forest plot from the 2-stage individual participant data (IPD) meta-analysis showing the hazard ratio (95%CI) for the major adverse cardiac and cerebrovascular events (MACCEs) and for individual components of the MACCEs. Repeat revascularization was excluded because it was only included in the RICADSSA trial. The area of the squares is proportional to the study weight and diamonds represent pooled hazard ratios (95% CIs). The dashed line depicts a null effect. ISAACC indicates Impact of Sleep Apnea Syndrome in the Evolution of Acute Coronary Syndrome⁷; RICCADSA, Randomized Intervention With CPAP in Coronary Artery Disease and Sleep Apnea⁸; and SAVE, Sleep Apnea Cardiovascular Endpoints.⁶