Table 2.

Rate of change of first antiretroviral treatment

First antiretroviral combination	Number of patients	Number stopped	Follow up (years)	Rate (per 100 person-years)	95% CI (per 100 person-years)
NNRTI-based	1016	395	1504.6	26.3	23.8–29.0
d4T/3TC/NVP	404	131	586.9	22.3	18.8–26.5
Other NNRTI-based*	612	264	917.7	28.8	25.5–32.5
3TC/ZDV/EFV	201	67	309.9	21.6	17.0–27.5
3TC/ZDV/NVP	120	51	160.6	31.8	24.1–41.8
3TC/d4T/EFV	112	38	180.7	21.0	15.3–28.9
ddI/d4T/EFV	76	48	151.8	31.6	23.8–42.0
ddI/d4T/NVP	56	35	47.9	73.1	52.5–101.8
Other	47	25	66.8	37.4	25.3–55.4
PI-based	13	5	13.5	36.9	15.4–88.7
Three or more, NRTI only	230	181	334.9	54.1	46.7–62.5
Mono/double therapy	443	422	424.4	99.4	90.4–109.4
Total	1702	1003	2277.4	44.0	41.4–46.9

^*Excluding d4T/3TC/NVP.

CI, confidence interval; d4T, stavudine; 3TC, lamivudine; NVP, nevirapine; ZDV, zidovudine; EFV, efavirenz; ddI, didanosine; NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, nonnucleoside reverse transcriptase inhibitor; PI, protease inhibitor.