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. Author manuscript; available in PMC: 2023 Oct 4.
Published in final edited form as: J Med Chem. 2021 May 23;64(11):7702–7723. doi: 10.1021/acs.jmedchem.1c00408

Scheme 2. Synthesis of Intermediate 13a.

Scheme 2.

aReagents and conditions: (a) Thionyl chloride (2.5 equiv), MeOH, 0 °C to r.t., 62%; (b) Fmoc-Cl (1.05 equiv), Et3N (3.75 equiv), dichloromethane, 0 °C to r.t., 81%; (c) hydrazine monohydrate (5 equiv), MeOH, r.t., 49%.