Comparison 6. Adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
6.1 Vomiting: delayed versus immediate antibiotics	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1.1 Delayed (prescription at time of visit) versus immediate antibiotics	2	494	Odds Ratio (M‐H, Random, 95% CI)	4.92 [0.19, 125.22]
6.1.2 Delayed (prescription collection) versus immediate antibiotics	1	413	Odds Ratio (M‐H, Random, 95% CI)	1.00 [0.49, 2.04]
6.1.3 Delayed (all strategies) versus immediate antibiotics	3	907	Odds Ratio (M‐H, Random, 95% CI)	2.82 [0.43, 18.45]
6.2 Vomiting: delayed (prescription collection) versus no antibiotics	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected
6.3 Diarrhoea: delayed versus immediate antibiotics	4		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
6.3.1 Delayed (prescription at time of visit) versus immediate antibiotics	2	394	Odds Ratio (M‐H, Random, 95% CI)	0.46 [0.15, 1.36]
6.3.2 Delayed (prescription collection) versus immediate antibiotics	2	674	Odds Ratio (M‐H, Random, 95% CI)	0.72 [0.26, 2.03]
6.3.3 Delayed (all strategies) versus immediate antibiotics	4	1068	Odds Ratio (M‐H, Random, 95% CI)	0.58 [0.29, 1.17]
6.4 Diarrhoea: delayed (prescription collection) versus no antibiotics	1	468	Odds Ratio (M‐H, Random, 95% CI)	1.43 [0.74, 2.78]
6.5 Rash: delayed (prescription collection) versus immediate antibiotics	2	665	Odds Ratio (M‐H, Random, 95% CI)	0.96 [0.50, 1.85]
6.6 Rash: delayed (prescription collection) versus no antibiotics	1		Odds Ratio (M‐H, Random, 95% CI)	Totals not selected