Table 5.

The comparison between the performance of DrugRep-HeSiaGraph and DrugRep-KG based on four versions of DDKGs

Model	DDKG version	ACC (%)	AUC-ROC (%)	AUC-PR (%)	BS (%)	MCC (%)	F1-score (%)
DrugRep-HeSiaGraph	DDKG-V1	$84.63\pm 0.02$	$91.16\pm 0.04$	$90.32\pm 0.13$	$11.90\pm 0.04$	$69.31\pm 0.82$	$83.13\pm 0.12$
	DDKG-V2	$83.44\pm 0.10$	$90.63\pm 0.07$	$90.09\pm 0.19$	$12.01\pm 0.05$	$67.53\pm 0.13$	$80.54\pm 0.27$
	DDKG-V3	$84.51\pm 0.04$	$90.97\pm 0.03$	$90.27\pm 0.41$	$12.00\pm 0.04$	$69.12\pm 0.14$	$82.84\pm 0.08$
	DDKG-V4	$83.91\pm 0.08$	$91.15\pm 0.10$	$90.17\pm 0.27$	$12.06\pm 0.03$	$67.90\pm 0.35$	$82.08\pm 0.19$
DrugRep-KG	DDKG-V1	$83.9$ 3	$91.00$	$90.30$	$11.97$	$67.90$	$82.83$
	DDKG-V2	$83.92$	$90.57$	$89.94$	$12.18$	$67.50$	$83.04$
	DDKG-V3	$82.45$	$91.03$	$90.18$	$12.15$	$64.99$	$82.73$
	DDKG-V4	$82.45$	$90.94$	$89.97$	$12.24$	$64.92$	$81.89$
DisDrugPred	–	–	58.73	53.45	38.91	–	–
DRP-VEM	–	52.33	55.37	55.12	29.76	32.43	52.35